In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
نویسندگان
چکیده
منابع مشابه
In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
Polyglutamine diseases, including Huntington's disease and a number of spinocerebellar ataxias, are caused by expanded CAG repeats that are located in translated sequences of individual, functionally-unrelated genes. Only mutant proteins containing polyglutamine expansions have long been thought to be pathogenic, but recent evidence has implicated mutant transcripts containing long CAG repeats ...
متن کاملO-42: Expansion of CAG Repeats in theSpinocerebellar Ataxia Type 1 (SCA1) Gene inIdiopathic Oligozoospermia Patients
Background: The lengths of CAG repeats in two spinocerebellar ataxia genes, SCA1 and SCA3, were analyzed to determine whether such repeats exist in higher numbers in infertile males. Materials and Methods: Blood samples were collected from healthy controls, oligozoospermia patients, and azoospermia patients. DNA fragments containing target CAG repeats were amplified by PCR with template DNA pur...
متن کاملP-118: Triplet Nucleotide Repeats Expansion (CAG and GGN) of Androgen Receptor Gene in Infertile Patients with Abnormal Spermogram
Background s:648:"The infertility has recently been estimated to affect approximately 9% of couples worldwide. Androgens and a functional androgen receptor (AR) are essential for normal development of the male gender, and for maintenance of spermatogenesis throughout the life. Two polymorphic trinucleotide repeats, CAG and GGN, encoding for the amino acids glutamine and glycine, respectively ar...
متن کاملInterruption of perfect CAG repeats by CAA triplets improves the stability of glutamine-encoding repeat sequences.
Several disorders are caused by the genomic expansion of a trinucleotide repeat beyond a specific critical size in the coding region of genes. The largest group of these diseases, which includes Huntington’s disease and the spinocerebellar ataxias of type 1, 2, 3, 6, and 7, are caused by expansion of a CAG repeat resulting in proteins with an expanded polyglutamine stretch (14). A correlation b...
متن کاملTta Aat Aat Tgc Cag Caa
In order to discern sake yeast, shochu yeast, and wine yeast, a specific polymerase chain reaction (PCR) was investigated. PCR products between shochu yeast strains and sake yeast weredistinguished by using a primer designed with an open reading frame of FLO5. Wine yeasts and most of other yeasts were distinguished by a primer designed with an open reading frame of YHR213W.However, PCR products...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2015
ISSN: 1422-0067
DOI: 10.3390/ijms160818741